全文获取类型
收费全文 | 2975篇 |
免费 | 294篇 |
国内免费 | 210篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 6篇 |
妇产科学 | 7篇 |
基础医学 | 72篇 |
口腔科学 | 4篇 |
临床医学 | 295篇 |
内科学 | 1122篇 |
皮肤病学 | 2篇 |
神经病学 | 8篇 |
特种医学 | 433篇 |
外国民族医学 | 4篇 |
外科学 | 282篇 |
综合类 | 516篇 |
预防医学 | 49篇 |
药学 | 162篇 |
中国医学 | 42篇 |
肿瘤学 | 474篇 |
出版年
2024年 | 5篇 |
2023年 | 73篇 |
2022年 | 133篇 |
2021年 | 199篇 |
2020年 | 193篇 |
2019年 | 128篇 |
2018年 | 172篇 |
2017年 | 162篇 |
2016年 | 173篇 |
2015年 | 209篇 |
2014年 | 281篇 |
2013年 | 246篇 |
2012年 | 190篇 |
2011年 | 211篇 |
2010年 | 165篇 |
2009年 | 196篇 |
2008年 | 140篇 |
2007年 | 139篇 |
2006年 | 108篇 |
2005年 | 99篇 |
2004年 | 51篇 |
2003年 | 48篇 |
2002年 | 33篇 |
2001年 | 29篇 |
2000年 | 28篇 |
1999年 | 15篇 |
1998年 | 15篇 |
1997年 | 8篇 |
1996年 | 5篇 |
1995年 | 10篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有3479条查询结果,搜索用时 15 毫秒
81.
82.
83.
Hao-Min Cheng Ling-Jan Chiou Tzu-Ching Chen Shih-Hsien Sung Chen-Huan Chen Hui-Chu Lang 《Health policy (Amsterdam, Netherlands)》2019,123(2):229-234
Objective
To evaluate the cost-effectiveness of using drugeluting stents (DES) compared to bare-metal stents (BMS) for coronary heart disease (CHD).Data sources/study setting
Data were obtained from the National Health Insurance Longitudinal Health Insurance Database, which contains claims data for 1,000,000 beneficiaries. The data were randomly sampled from all beneficiaries.Study design
A retrospective claims data analysis.Data collection/extraction methods
Patients with stable coronary heart disease who underwent coronary stent implantation from 2007 to 2008 were recruited and followed to the end of 2013. After a 2:1 propensity score matched by gender, age, stent number, and the Charlson comorbidity index (CCI), 852 patients with 568 stents in the BMS group and 284 stents in the DES group were included. The cumulative medical costs for both matched groups were estimated with the Kaplan-Meier Sample Average (KMSA), and then the incremental cost-effectiveness ratio (ICER) was estimated.Principal findings
The ICER of DES vs. BMS was NT$ 663,000 per cardiovascular death averted and NT$ 238,394 per cardiovascular death or coronary event averted in five years from the insurer perspective.Conclusion
Percutaneous coronary intervention (PCI) with DES was a more cost-effective strategy than PCI with BMS for CHD patients during the five-year follow-up. 相似文献84.
85.
Mahesh V. Madhavan Bernard J. Gersh Karen P. Alexander Christopher B. Granger Gregg W. Stone 《Journal of the American College of Cardiology》2018,71(18):2015-2040
Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients ≥80 years of age. Nonetheless, older patients have typically been under-represented in cardiovascular clinical trials. Understanding the pathophysiology, epidemiology, and optimal means of diagnosis and treatment of CAD in older adults is crucial to improving outcomes in this high-risk population. A patient-centered approach, taking into account health status, functional ability and frailty, cognitive skills, and patient preferences is essential when caring for older adults with CAD. The present systematic review focuses on the current knowledge base, gaps in understanding, and directions for future investigation pertaining to CAD in patients ≥80 years of age. 相似文献
86.
《JACC: Cardiovascular Interventions》2014,7(10):1103-1104
87.
An estimated rise in liver cancer incidence will increase to 95374 new cases by 2020. Hepatocellular Carcinoma (HCC), the most common primary malignant tumour of the liver, is considered to be the third leading cause of all cancer-related deaths and fifth common cancer worldwide. The reported data shows that the rate of HCC incidence in male population is three to four times higher compared with the female population. In the United States, HCV-induced liver cancer is increasing very fast because of the lack of proper treatment option. There are various treatment strategies available for HCC like liver transplantation, resection, ablation, embolization and chemotherapy still the prognosis is destitute. If the patient is eligible, liver transplantation is the only therapeutic option that may give around 90% survival rate, but the scarcity of liver donor limits its broad applicability. A sudden address is necessary to develop specific drugs, personalized medicine, for HCC. 相似文献
88.
Xiao Wu Julius Chapiro Ajay Malhotra Nishita Kothary 《Journal of vascular and interventional radiology : JVIR》2021,32(1):2-12.e1
PurposeTo compare the cost-effectiveness of using doxorubicin-loaded drug-eluting embolic (DEE) transarterial chemoembolization versus that of using conventional transarterial chemoembolization for patients with unresectable hepatocellular carcinoma (HCC).Materials and MethodsA decision-analysis model was constructed over the lifespan of a payer’s perspective. The model simulated the clinical course, including periprocedural complications, additional transarterial chemoembolization or other treatments (ablation, radioembolization, or systemic treatment), palliative care, and death, of patients with unresectable HCC. All clinical parameters were derived from the literature. Base case calculations, probabilistic sensitivity analyses, and multiple two-way sensitivity analyses were performed.ResultsIn the base case calculations for patients with a median age of 67 years (range for conventional transarterial chemoembolization: 28–88 years, range for DEE-transarterial chemoembolization: 16–93 years), conventional transarterial chemoembolization yielded a health benefit of 2.11 quality-adjusted life years (QALY) at a cost of $125,324, whereas DEE-transarterial chemoembolization yielded 1.71 QALY for $144,816. In 10,000 Monte Carlo simulations, conventional transarterial chemoembolization continued to be a more cost-effective strategy. conventional transarterial chemoembolization was cost-effective when the complication risks for both the procedures were simultaneously varied from 0% to 30%. DEE-transarterial chemoembolization became cost-effective if the conventional transarterial chemoembolization mortality exceeded that of DEE-transarterial chemoembolization by 17% in absolute values. The two-way sensitivity analyses demonstrated that conventional transarterial chemoembolization was cost-effective until the risk of disease progression was >0.4% of that for DEE-transarterial chemoembolization in absolute values. Our analysis showed that DEE-transarterial chemoembolization would be more cost-effective if it offered >2.5% higher overall survival benefit than conventional transarterial chemoembolization in absolute values.ConclusionsCompared with DEE-transarterial chemoembolization, conventional transarterial chemoembolization yielded a higher number of QALY at a lower cost, making it the more cost-effective of the 2 modalities. 相似文献
89.
目的通过中华实验用小型猪冠状动脉再狭窄模型,观察中药莪术组分涂层支架抑制内膜增殖的有效性。方法将18只小型猪随机分为莪术组分涂层支架组(ZES组)、雷帕霉素涂层支架组(SES组)及金属裸支架组(BMS组),每组6只,分别在左前降支、左回旋支及右冠状动脉置入同一种支架各1枚。术后30 d冠状动脉造影后将猪处死,观察支架血管段的病理形态及影像学变化。结果 30 d时,与BMS组比较,ZES组和SES组平均管腔直径和平均管腔面积均明显增大(P<0.05),直径狭窄率和面积狭窄率明显减小(P<0.05);与SES组比较,ZES组和BMS组炎症积分明显降低,内皮化积分明显升高(P<0.05);3组损伤积分比较,差异无统计学意义(P>0.05);光学相干断层扫描及扫描电镜观察,SES支架组30 d时可见部分支架节段内皮化不全及炎性细胞浸润。结论 ZES支架可有效地抑制血管内膜增殖,具有良好的生物相容性。 相似文献
90.